Recent Publications

Duodenal organoids from metabolic dysfunction-associated steatohepatitis patients exhibit absorptive and barrier alterations
Alia Hadefi, Morgane Leprovots, Gilles Dinsart, Maryam Marefati, Marjorie Vermeersch, Daniel Monteyne, David Pérez-Morga, Anne Lefort, Frédérick Libert, Laurine Verset, Claire Liefferinckx, Christophe Moreno, Jacques Devière, Eric Trépo, Marie-Isabelle Garcia, Gastro Hep Advances, 2024, 100599, ISSN 2772-5723, https://doi.org/10.1016/j.gastha.2024.100599.

Non-apical mitoses contribute to cell delamination during mouse gastrulation
Despin-Guitard E, Rosa VS, Plunder S, Mathiah N, Van Schoor K, Nehme E, Merino-Aceituno S, Egea J, Shahbazi MN, Theveneau E, Migeotte I. Nat Commun 15, 7364 (2024).
![Impact of benzo[a]pyrene, PCB153 and sex hormones on human ESC-Derived thyroid follicles using single cell transcriptomics](https://images.squarespace-cdn.com/content/v1/679b4754f028f15dccd6fc66/1738850282012-0RQ3RNM6X45JPX151R50/pub-thumbnail-iribhm.png)
Impact of benzo[a]pyrene, PCB153 and sex hormones on human ESC-Derived thyroid follicles using single cell transcriptomics
Marta Nazzari, Mírian Romitti, Anna M. Kip, Rick Kamps, Sabine Costagliola, Twan van de Beucken, Lorenzo Moroni, Florian Caiment, Environment International, 2024, https://doi.org/10.1016/j.envint.2024.108748.

Origin and flow-mediated remodeling of the murine and human extraembryonic circulation systems
Van Schoor Kristof , Bruet Emmanuel , Jones Elizabeth Anne Vincent , Migeotte Isabelle. Frontiers in Physiology, Volume 15 – 2024 |https://doi.org/10.3389/fphys.2024.1395006

STR mutations on chromosome 15q cause thyrotropin resistance by activating a primate-specific enhancer of MIR7-2/MIR1179
Grasberger H, Dumitrescu A M, Liao X-H, Swanson E G, Weiss R E, Srichomkwun P, Pappa T, Chen J, Yoshimura T, Hoffmann P, França M M, Tagett R, Onigata K, Costagliola S, Ranchalis J, Vollger M R, Stergachis A B, Chong J X, Bamshad M J, Smits G, Vassart G and Refetoff S, Nature Genetics (2024) https://doi.org/10.1038/s41588-024-01717-7

An Lgr5-independent developmental lineage is involved in mouse intestinal regeneration
Marefati, M., Fernandez-Vallone, V., Leprovots, M., Vasile, G., Libert, F., Lefort, A., Dinsart, G., Weber, A., Jetzer, J., Garcia, M.-I., Vassart, G. bioRxiv Subject Collection: Developmental Biology / 2024-03-14 22:00

The olfactory receptor olfr78 promotes differentiation of enterochromaffin cells in the mouse colon
Gilles Dinsart, Morgane Leprovots, Anne Lefort, Frederick Libert, Yannick Quesnel, Alex Veiten, Gilbert Vassart, Sandra Huysseune, Marc Parmentier, Marie-Isabelle Garcia. EMBO reports, (2023); https://doi.org/10.1038/s44319-023-00013-5

Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids
H. Lasolle, A. Schiavo, A. Tourneur, P. Gillotay, B. de F. da Fonseca, L. Ceolin, O. Monestier, B. Aganahi, L. Chomette, M. M. L. Kizys, L. Haenebalcke, T. Pieters, S. Goossens, J. Haigh, V. Detours, A. L. S. Maia, S. Costagliola, and M. Romitti, Oncogene 1–16 (2023) doi:10.1038/s41388-023-02889-y.

Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration
Mírian Romitti, Sabine Costagliola, Endocrinology, 2023;, bqad136, https://doi.org/10.1210/endocr/bqad136

A Systematic Review and Meta-analysis
Degeneffe A, De Maertelaer V, De Witte O, Lefranc F.The Association Between Meningioma and Breast Cancer: JAMA Netw Open. 2023 Jun 1;6(6):e2318620. https://doi: 10.1001/jamanetworkopen.2023.18620.

RHOJ controls EMT-associated resistance to chemotherapy
Debaugnies M, Rodríguez-Acebes S, Blondeau J, Parent MA, Zocco M, Song Y, De Maertelaer V, Moers V, Latil M, Dubois C, Coulonval K, Impens F, Van Haver D, Dufour S, Uemura A, Sotiropoulou PA, Méndez J, Blanpain C.Nature. 2023 Apr;616(7955):168-175. doi: 10.1038/s41586-023-05838-7. Epub 2023 Mar 22.

The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes
Simon Ullrich, Susanne Leidescher, Yana Feodorova, Katharina Thanisch, Jean-Baptiste Fini, Bernd Kaspers, Frank Weber, Boyka Markova, Dagmar Fuehrer, Mirian Romitti, Stefan Krebs, Helmut Blum, Heinrich Leonhardt, Sabine Costagliola, Heike Heuer, Irina Solovei Front. Cell Dev. Biol. 11, 1265407 (2023).

Mesodermal FGF and BMP govern the sequential stages of zebrafish thyroid specification
Benoit Haerlingen, Robert Opitz, Isabelle Vandernoot, Angelo Molinaro, Meghna Parakkal Shankar, Pierre Gillotay, Achim Trubiroha, Sabine Costagliola; Development 2023; dev.201023. doi: https://doi.org/10.1242/dev.201023

Single-cell transcriptomics uncovers the differentiation of a subset of murine esophageal progenitors into taste buds in vivo
Vercauteren Drubbel A, Beck B. Sci Adv. 2023 Mar 10;9(10):eadd9135. doi: 10.1126/sciadv.add9135. Epub 2023 Mar 8. PMID: 36888721; PMCID: PMC9995038.

Zebrafish Galectin 3 binding protein is the target antigen of the microglial 4C4 monoclonal antibody
Rovira M, Miserocchi M, Montanari A, Hammou L, Chomette L, Pozo J, Imbault V, Bisteau X, Wittamer V. Dev Dyn. 2023 Mar;252(3):400-414. https://doi.org/10.1002/dvdy.549

Dynamic Cancer Cell Heterogeneity: Diagnostic and Therapeutic Implications
Cancers 14 (2) 280.Jacquemin V., Antoine M., Dom G., Detours V., Maenhaut C., Dumont J.E. (2022)

Microglia states and nomenclature: A field at its crossroads
Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, González B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T. Neuron. 2022 Nov 2;110(21):3458-3483. https://doi.org/10.1016/j.neuron.2022.10.020

Emerging Technologies in Thyroid Biology: Pushing the Frontiers of Thyroid Research
Costagliola, S., Singh, S. Molecular and Cellular Endocrinology, https://doi.org/10.1016/j.mce.2023.111912

Thyroid-on-a-chip: An Organoid Platform For In Vitro Assessment of Endocrine Disruption
Carvalho, D. J., Kip, A. M., Romitti, M., Nazzari, M., Tegel, A., Stich, M., Krause, C., Caiment, F., Costagliola, S., Moroni, L., Giselbrecht, S., Adv. Healthcare Mater. 2022, 2201555. https://doi.org/10.1002/adhm.202201555

Loss-of-function N178T variant of the human P2Y4 receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis
Michael Horckmans, Esteban Diaz Villamil, Céline Verdier, Henrik Laurell, H., Jean-Bernard Ruidavets, Lucas De Roeck, Guillaume Combes, Laurent O. Martinez and Didier Communi. Frontiers in Pharmacology (2022) https://doi.org/10.3389/fphar.2022.1049696