Recent Publications
Profiling the complex rearrangement architecture of sarcoma
S Waise, T Lesluyes, J Demeulemeester, M Tarabichi, AM Flanagan, N Pillay, P Van Loo. Journal of Pathology 2024/8/1
Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction
Adriana Salcedo, Maxime Tarabichi, Alex Buchanan, Shadrielle MG Espiritu, Hongjiu Zhang, Kaiyi Zhu, Tai-Hsien Ou Yang, Ignaty Leshchiner, Dimitris Anastassiou, Yuanfang Guan, Gun Ho Jang, Mohammed FE Mootor, Kerstin Haase, Amit G Deshwar, William Zou, Imaad Umar, Stefan Dentro, Jeff A Wintersinger, Kami Chiotti, Jonas Demeulemeester, Clemency Jolly, Lesia Sycza, Minjeong Ko, David C Wedge, Quaid D Morris, Kyle Ellrott, Peter Van Loo, Paul C Boutros. Nature Biotechnology 2024/6/11 https://www.nature.com/articles/s41587-024-02250-y
Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of pleural mesotheliomas to CDK4/6 inhibition
Sabine Paternot, Eric Raspé, Clément Meiller, Maxime Tarabichi, Jean‐Baptiste Assié, Frederick Libert, Myriam Remmelink, Xavier Bisteau, Patrick Pauwels, Yuna Blum, Nolwenn Le Stang, Séverine Tabone‐Eglinger, Françoise Galateau‐Sallé, Christophe Blanquart, Jan P Van Meerbeeck, Thierry Berghmans, Didier Jean, Pierre P Roger. Molecular Oncology 2024/4 https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13351
Genomic evolution shapes prostate cancer disease type
Dan J Woodcock, Atef Sahli, Ruxandra Teslo, Vinayak Bhandari, Andreas J Gruber, Aleksandra Ziubroniewicz, Gunes Gundem, Yaobo Xu, Adam Butler, Ezequiel Anokian, Bernard J Pope, Chol-Hee Jung, Maxime Tarabichi, Stefan C Dentro, J Henry R Farmery, Peter Van Loo, Anne Y Warren, Vincent Gnanapragasam, Freddie C Hamdy, G Steven Bova, Christopher S Foster, David E Neal, Yong-Jie Lu, Zsofia Kote-Jarai, Michael Fraser, Robert G Bristow, Paul C Boutros, Anthony J Costello, Niall M Corcoran, Christopher M Hovens, Charlie E Massie, Andy G Lynch, Daniel S Brewer, Rosalind A Eeles, Colin S Cooper, David C Wedge. Cell Genomics 2024/3/13 https://www.cell.com/cell-genomics/fulltext/S2666-979X(24)00038-7
Aneuploidy and complex genomic rearrangements in cancer evolution
Toby M Baker, Sara Waise, Maxime Tarabichi, Peter Van Loo. Nature cancer 2024/2. https://www.nature.com/articles/s43018-023-00711-y
Pan-cancer subclonal mutation analysis of 7,827 tumors predicts clinical outcome
Yujie Jiang, Matthew D Montierth, Kaixian Yu, Shuangxi Ji, Shuai Guo, Quang Tran, Xiaoqian Liu, Seung Jun Shin, Shaolong Cao, Ruonan Li, Yuxin Tang, Tom Lesluyes, Scott Kopetz, Jaffer Ajani, Pavlos Msaouel, Sumit K Subudhi, Ana Aparicio, Padmanee Sharma, John Paul Shen, Anil K Sood, Maxime Tarabichi, Jennifer R Wang, Marek Kimmel, Peter Van Loo, Hongtu Zhu, Wenyi Wang. bioRxiv 2024.07. 03.601939 https://www.biorxiv.org/content/10.1101/2024.07.03.601939v1.abstract
Single nuclei and spatial transcriptomes suggest a stratification of papillary and anaplastic thyroid cancer cells
Adrien Tourneur, Joel Rodrigues Vitoria, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frederick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours. bioRxiv 2024.02. 15.580495 https://www.biorxiv.org/content/10.1101/2024.02.15.580495v2.abstract
Understanding the dosage-dependent role of Dicer1 in thyroid tumorigenesis
Rojo-Pardillo M.; Godefroid, L.; Dom, G.; Lefort, A.; Libert, F.; Robaye, B.; Maenhaut, C. International Journal of Molecular Sciences 2024, 25, 10701. https://doi.org/10.3390/ijms251910701
A Systematic Review and Meta-analysis
Degeneffe A, De Maertelaer V, De Witte O, Lefranc F.The Association Between Meningioma and Breast Cancer: JAMA Netw Open. 2023 Jun 1;6(6):e2318620. https://doi: 10.1001/jamanetworkopen.2023.18620.
RHOJ controls EMT-associated resistance to chemotherapy
Debaugnies M, Rodríguez-Acebes S, Blondeau J, Parent MA, Zocco M, Song Y, De Maertelaer V, Moers V, Latil M, Dubois C, Coulonval K, Impens F, Van Haver D, Dufour S, Uemura A, Sotiropoulou PA, Méndez J, Blanpain C.Nature. 2023 Apr;616(7955):168-175. doi: 10.1038/s41586-023-05838-7. Epub 2023 Mar 22.
Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of malignant pleural mesotheliomas to CDK4/6 inhibition
Paternot S, Raspé E, Meiller C, Tarabichi M, Assié JB, Libert F, Remmelink M, Bisteau X, Pauwels P, Blum Y, Le Stang N, Tabone-Eglinger S, Galateau-Salle F, Blanquart C, Van Meerbeeck JP, Berghmans T, Jean D, Roger PP. bioRxiv (april 2022) doi: https://doi.org/10.1101/2022.04.11.487857
Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia
Vercauteren Drubbel A, Pirard S, Kin S, Dassy B, Lefort A, Libert F, Nomura S, Beck B. Cell Stem Cell. 2021 Apr 14:S1934-5909(21)00152-1. doi: 10.1016/j.stem.2021.03.019. Epub ahead of print. PMID: 33882290.