Recent Publications
Single nuclei and spatial transcriptomes suggest a stratification of papillary and anaplastic thyroid cancer cells
Adrien Tourneur, Joel Rodrigues Vitoria, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frederick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours. bioRxiv 2024.02. 15.580495 https://www.biorxiv.org/content/10.1101/2024.02.15.580495v2.abstract
Understanding the dosage-dependent role of Dicer1 in thyroid tumorigenesis
Rojo-Pardillo M.; Godefroid, L.; Dom, G.; Lefort, A.; Libert, F.; Robaye, B.; Maenhaut, C. International Journal of Molecular Sciences 2024, 25, 10701. https://doi.org/10.3390/ijms251910701
Impact of benzo[a]pyrene, PCB153 and sex hormones on human ESC-Derived thyroid follicles using single cell transcriptomics
Marta Nazzari, Mírian Romitti, Anna M. Kip, Rick Kamps, Sabine Costagliola, Twan van de Beucken, Lorenzo Moroni, Florian Caiment, Environment International, 2024, https://doi.org/10.1016/j.envint.2024.108748.
STR mutations on chromosome 15q cause thyrotropin resistance by activating a primate-specific enhancer of MIR7-2/MIR1179
Grasberger H, Dumitrescu A M, Liao X-H, Swanson E G, Weiss R E, Srichomkwun P, Pappa T, Chen J, Yoshimura T, Hoffmann P, França M M, Tagett R, Onigata K, Costagliola S, Ranchalis J, Vollger M R, Stergachis A B, Chong J X, Bamshad M J, Smits G, Vassart G and Refetoff S, Nature Genetics (2024) https://doi.org/10.1038/s41588-024-01717-7
The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes
Simon Ullrich, Susanne Leidescher, Yana Feodorova, Katharina Thanisch, Jean-Baptiste Fini, Bernd Kaspers, Frank Weber, Boyka Markova, Dagmar Fuehrer, Mirian Romitti, Stefan Krebs, Helmut Blum, Heinrich Leonhardt, Sabine Costagliola, Heike Heuer, Irina Solovei Front. Cell Dev. Biol. 11, 1265407 (2023).
Emerging Technologies in Thyroid Biology: Pushing the Frontiers of Thyroid Research
Costagliola, S., Singh, S. Molecular and Cellular Endocrinology, https://doi.org/10.1016/j.mce.2023.111912
Thyroid-on-a-chip: An Organoid Platform For In Vitro Assessment of Endocrine Disruption
Carvalho, D. J., Kip, A. M., Romitti, M., Nazzari, M., Tegel, A., Stich, M., Krause, C., Caiment, F., Costagliola, S., Moroni, L., Giselbrecht, S., Adv. Healthcare Mater. 2022, 2201555. https://doi.org/10.1002/adhm.202201555
Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
Mírian Romitti, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Adrien Tourneur, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff, Sabine Costagliola Nat Commun 13, 7057 (2022). https://doi.org/10.1038/s41467-022-34776-7, https://doi.org/10.1038/s41467-022-34776-7
Murine Thyroid IL-4 Expression Worsens Hypothyroidism on Iodine Restriction and Mitigates Graves Disease Development
Merakchi K, Djerbib S, Soleimani M, Dumont JE, Miot F, De Deken X. Endocrinology. 2022 Sep 1;163(9):bqac107. doi: 10.1210/endocr/bqac107.PMID: 35881515
Foxe1 orchestrates thyroid and lung cell lineage divergence in mouse stem cell-derived organoids
Fonseca B F, Barbee C, Romitti M, Eski S E, Gillotay P, Monteyne D, Perez-Morga D, Refetoff S, Singh S P and Costagliola S 2022 bioRxiv 2022.05.16.492074. https://doi.org/doi:10.1101/2022.05.16.492074.
Nrf2 promotes thyroid development and hormone synthesis
Pierre Gillotay, Mirian Romitti, Benjamin Dassy, Benoit Haerlingen, Meghna Parakkal Shankar, Barbara De Faria Da Fonseca, Panos G. Ziros, Sumeet Pal Singh, Gerasimos Sykiotis, Sabine Costagliola. bioRxiv 2022.02.27.482168; doi: https://doi.org/10.1101/2022.02.27.482168
Transcriptomic signature of human embryonic thyroid reveals transition from differentiation to functional maturation
Dom G., Dmitriev P., Lambot MA., Van Vliet G., Glinoer D., Libert F., Lefort A., Dumont J.E., Maenhaut C. (2021) . Frontiers in Cell and Developmental Biology 9,
MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways
Augenlicht A., Saiselet M., Decaussin-Petrucci M., Andry G., Dumont J.E., Maenhaut C. (2021) Oncotarget 12, 1587-1599.
Single-cell trajectory inference guided enhancement of thyroid maturation in vitro using TGF-beta inhibition
M. Romitti, S. E. Eski, B. F. Fonseca, P. Gillotay, S. P. Singh, and S. Costagliola, Front Endocrinol12, 657195 (2021).
Single-cell transcriptome analysis reveals cell-cell communication and thyrocyte diversity in the zebrafish thyroid gland
P. Gillotay, M. P. Shankar, S. E. Eski, S. Reinhardt, A. Kraenkel, J. Blaesche, A. Petzold, G. Kesavan, C. Lange, M. Brand, V. Detours, S. Costagliola, and S. P. Singh, EMBO Rep, vol. n/a, no. n/a, p. e50612, Nov. 2020.