Isabelle Garcia – GHoPat

Our research


Intestinal stem cell biology Lab

The gastrointestinal epithelium is one of the tissues with highest self-renewing rates under steady-state conditions, thereby constituting an excellent model to better understand how adult stem cells contribute to tissue homeostasis, damage-induced regeneration processes or cancer. By combining in vivo mouse studies and ex vivo organoid technology, we are currently investigating:

– how stem cells emerge during late fetal development

– how the Lgr4/Lgr5 GPCR receptors regulate intestinal stem cell maintenance and differentiation

– regeneration processes

–> Link to GhoPat