Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire

Thyroid endocrinology

[ B .Corvilain , S.Costagliola , X. De Deken , J.E.Dumont , F. Miot , P.Roger , J.Van Sande , G.Vassart ]

Current research programs include the study of : the mechanisms of H2O2 production in thyrocytes, the regulation cAMP and inositolphosphate regulatory cascades by the TSH receptor, structure-function relationships of the TSH receptor, mechanisms of activation of the TSH receptor by the autoantibodies of Graves’disease, control of the proliferation of thyrocytes by cAMP- and growth factor-dependent mechanisms, the regulation of gene expression in thyrocytes by cAMP, the mechanisms responsible for the development of congenital hypothyroidism.


Main recent publications

De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F.

Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.
J Biol Chem. 275:23227-33 (2000).

Perry R, Heinrichs C, Bourdoux P, Khoury K, Szots F, Dussault JH, Vassart G, Van Vliet G.

Discordance of monozygotic twins for thyroid dysgenesis: implications for screening and for molecular pathophysiology.
J Clin Endocrinol Metab. 87:4072-7 (2002).

Costagliola S, Bonomi M, Morgenthaler NG, Van Durme J, Panneels V, Refetoff S, Vassart G.

Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity.
Mol Endocrinol. 18:3020-34. (2004).

Grasberger H, Vaxillaire M, Pannain S, Beck JC, Mimouni-Bloch A, Vatin V, Vassart G, Froguel P, Refetoff S.

Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1.
Hum Genet. 118:348-55 (2005).

Grasberger H, Mimouni-Bloch A, Vantyghem MC, van Vliet G, Abramowicz M, Metzger DL, Abdullatif H, Rydlewski C, Macchia PE, Scherberg NH, van Sande J, Mimouni M, Weiss RE, Vassart G, Refetoff S.

Autosomal dominant resistance to thyrotropin as a distinct entity in five multigenerational kindreds: clinical characterization  and exclusion of candidate loci.
J Clin Endocrinol Metab. 90:4025-34 (2005).

Grasberger H, Ringkananont U, Lefrancois P, Abramowicz M, Vassart G, Refetoff S.

Thyroid transcription factor 1 rescues PAX8/p300 synergism impaired by a natural PAX8 paired domain mutation with dominant negative activity.
Mol Endocrinol. 19:1779-91 (2005)

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